Studies on the Induction of Bone and Soft Tissue Tumours in Rats by Gamma Irradiation and the Effect of Growth Hormone and Thyroxine
A single dose of 3000 roentgen of gamma irradiation from a iridium-192 teletherapy source applied to both knee joints of growing female rats induced osteosarcomata in 34 out of 116 rats. Fifty rats developed sarcomata of soft tissues, 10 cancer of the skin, and 12 had mammary cancers. Eighty days after irradiation, ten-week courses of growth hormone, thyroxine, growth hormone followed by thyroxine, and saline were given to study the effect of hormone treatment on the incidence and induction period of radiationinduced bone sarcomata. Twelve out of 30 growthhormone-treated rats developed bone sarcomata compared with 7 out of 31 in the saline injected group. Thyroxine treatment significantly reduced the mean latent period of radiation-induced osteosarcomata. The incidence of other types of malignant tumors was not affected by the hormone treatments.
- Research Organization:
- Univ. of Cambridge, Eng.; Northwestern Univ., Chicago; Argonne National Lab., Lemont, Ill.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-010347
- OSTI ID:
- 4188879
- Journal Information:
- British Journal of Cancer, Vol. 13, Issue 2; Other Information: Orig. Receipt Date: 31-DEC-60; ISSN 0007-0920
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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