Cancer in the Rat after Single Exposures to Irradiation or Hydrocarbons: Age and Strain Factors. Hormone Dependence of the Mammary Cancers

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Radiation Research

DOI:https://doi.org/10.2307/3571380· OSTI ID:4148859

Huggins, Charles; Fukunishi, Ryo

Single whole-body x irradiation (400 r) exerted selective cell damage in female rats. Hemopoietic tissues were damaged, and cancer was induced selectively in mammary gland and fibroblast. Among the undamaged tissues were pituitary, ovary, and vagina, which remained functionally intact, since regular estrus cycles persisted. The racial strain of origin of the rats had a profound influence on the development of mammary cancer after whole-body irradiation. Females of the Sprague-Dawley strain developed both sarcoma and mammary carcinoma. In females of the LongEvans strain, sarcomas were induced but mammary carcinoma was not observed. The tumors characteristic of each strain arose when irradiation was provided to neonatal (age 3 days) or adult rats. Mammary carcinoma was detected soon after irradiation, and sarcoma at a later time. In Sprague-Dawley females given a single whole-body xirradiation (400 r) at age 52 days, mammary carcinomas had the following characteristics: incidence in 29.7% of rats; 92% of the cancers detected within 79 days; multiple carcinomas found in 13% of cancerous rats. In sisters given two x irradiations (400 r) at 52 and 92 days, mammary carcinomas had the following characteristics: incidence in 50% of rats; tumors detected in a continuous series from 25 to 220 days; multiple intravenous injection of 5 mg of 7,12-dimethylbenz (a) anthracene, was more efficient than x irradiation (400 r) in induction of mammary cancer; incidence, 100%; rats with multiple tumors, 68%. A newly recognized property of radioinduced mammary carcinoma of rat is hormone dependence of the cancers. Mammary carcinomas in Sprague-Dawley rats, induced by radiation or by polycyclic aromatic hydrocarbons, shared the following qualities: similar histological appearance; similar regressive properties after ovariectomy; and similar content of the five dehydrogenases, glucose-8-phosphate, 8-phosphogluconic, isocitric, lactic, and malic. (auth)

• Research Organization: Univ. of Chicago
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-001427
• OSTI ID: 4148859
• Journal Information: Radiation Research, Journal Name: Radiation Research Journal Issue: 3 Vol. 20; ISSN 0033-7587
• Publisher: Radiation Research Society
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ALUMINUM
ANIMAL CELLS
AROMATICS
BIOLOGY AND MEDICINE
BLOOD FORMATION
BLOOD VESSELS
BODY
CANCER
CARCINOGENESIS
CARCINOMAS
CHROMIUM
CYTOLOGY
DEHYDROGENASES
EFFICIENCY
ENZYMES
FIBROBLASTS
GLANDS
GONADS
HORMONES
HYDROCARBONS
MAMMARY GLANDS
MECHANICAL PROPERTIES
METALS
MOLYBDENUM
OVARIES
PHYSIOLOGY
PITUITARY GLAND
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SARCOMAS
SEX
STEELS
SURGERY
TISSUES
TITANIUM
TUMORS
TUNGSTEN
VAGINA
VARIATIONS
X RADIATION
ZIRCONIUM