Spontaneous tumors in Sprague-Dawley and Long-Evans rats and in their F/sub 1/ hybrids: carcinogenic effect of total-body x irradiation

Journal Article · Thu Nov 01 04:00:00 EST 1979 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.76.11.5910· OSTI ID:5414135

Gross, L; Dreyfuss, Y

Rats frequently develop various tumors, many of them malignant; the majority of tumors in the females develop in the mammary glands. In primary spontaneous tumors and lymphomas virus particles cannot be found on electron microscopic examination; transmission of the tumors by filtered extracts has not been successful. In our colonies of Sprague-Dawley rats the incidence of tumors was 22% in females and 5% in males; in Long-Evans rats the incidence of tumors was 28% in females and 10% in males. In (Sprague-Dawley x Long-Evans) F/sub 1/ hybrids the incidence of tumors was 67% in females and 32% in males, about twice as high as in the parental strains. Fractionated total-body x-irradiation (150 rads five times at weeky intervals) (1 rad = 0.01 gray) increased the incidence of tumors in Sprague-Dawley rats from 22 to 93% in females and from 5 to 59% in males. In Long-Evans rats, irradiation increased the incidence of tumors from 28 to 63% in females and from 10 to 42% in males. The incidence of malignant tumors was almost twice as high in irradiated Sprague-Dawley and Long-Evans rats as compared with nonirradiated animals of the same strains. Partial shielding during irradiation had no significant effect on the incidence or on the forms of tumors developing in the irradiated animals. In striking contrast to results of experiments carried out on mice, the incidence of leukemia and lymphomas was not increased in the irradiated rats, as compared with control animals.

• Research Organization: Veterans Administration Medical Center, Bronx, NY
• OSTI ID: 5414135
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 76:11; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CARCINOMAS
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLANDS
HEMIC DISEASES
HYBRIDIZATION
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LYMPHOMAS
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RATS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION