IN VITRO LEUCINE INCORPORATION INTO PROTEIN OF NORMAL AND X-IRRADIATED RABBIT BONE MARROW CELLS

Journal Article · Tue Mar 01 04:00:00 EST 1960 · American Journal of Physiology (U.S.)

OSTI ID:4183807

Uyeki, E M; Key, H; Salerno, P R

When compared with nonirradiated controls, the isolated bone marrow cells of x-irradiated rabbits showed a decrease in the in vitro uptake of labeled leucine into proteins 1 and 2 days after exposure to 400 r and 800 r. A similar magnitude of inhibition of leucine incorporation was observed in hemibody x- irradiated rabbits in which the marrow cells from the irradiated femur were compared with that from the nonirradiated side. The decreased uptake of leucine into protein after radiation may be due to an interruption in the supply of young forms during the postirradiation period, and hence, the decreased uptake of amino acids into proieins may be characteristic of the mature cells of the surviving cellular elements. (auth)

• Research Organization: Western Reserve Univ. School of Medicine, Cleveland
• NSA Number: NSA-14-010345
• OSTI ID: 4183807
• Journal Information: American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 198; ISSN AJPHA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
AMINO ACIDS
ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
BONE MARROW
BONES
FEMUR
LABELLED COMPOUNDS
LEUCINE
METABOLISM
PROTEINS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION EFFECTS
X RADIATION