THE EFFECT OF IONIZING RADIATION, ADRENALECTOMY AND CORTISONE TREATMENT ON THE INTESTINAL ABSORPTION OF AMINO ACIDS
Protein assimilation, nitrogen balance, and the nitrogen and labile phosphorus contsnt of the intestinal wall of rats were virtually unaffected by x irradiation in doses of 400 r. When irradiation doses reached 500 to 600 r, the rate of amino acid absorption in the gut decreased. The stimulating effect of ATP, phosphate, and Mg-ion added with the mixture was less pronounced in irradiated animals than in normal controls. Adrenalectomy was found to decrease considerably the rate of amino acid absorption in the intestine. On the other hand, the intestinal absorption of amino acid mixtures and of histidine in animals treated with excess cortisone was considerably higher than in controls. Labile phosphorus concentration in the intestinal wall and in ine lumen contents was also decreased in the irradiated arimals compared to controls; it was also increased with cortisone treatment. The decreased ability of adrenalectomized and x-irradiated rats to absorb amino acid mixtures and pure histidine from the intestine indicates that the intestinal absorption of amino acids is coupled with their phosphorylation. (auth)
- Research Organization:
- Inst. of Nutrition, Academy of Medical Sciences, Moscow
- NSA Number:
- NSA-14-013589
- OSTI ID:
- 4173225
- Journal Information:
- Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 24
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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