Skin heparin levels and postheparin plasma clearing factor lipase levels in irradiated adrenalectomized and cortisone-treated rats
Experiments were carried out to determine whether changes in endogenous heparin in rat tissues were related to changes in plasma levels of clearing factor lipase (CFL). Skin heparin levels, postheparin plasma CFL levels, and peritoneal mast cell counts were measured in normal, adrenalectomized, cortisone- treated, and x irradiated rats. Total body x irradiation in doses of 400 to 600 r decreased skin heparin levels. The postheparin CFL levels of irradiated rats remained high while that of pair-fed controls dropped significantly. Cortisone treatment for 8 days caused an increase in plasma CFL levels in both intact and adrenalectomized rats but no significant change in skin heparin levels or mast cell count. Adrenalectomy caused no significant change in either postheparin CFL or skin heparin levels.
- Research Organization:
- Univ. of Toronto
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-037076
- OSTI ID:
- 4631197
- Journal Information:
- Can. J. Biochem. Physiol., Journal Name: Can. J. Biochem. Physiol. Vol. Vol: 41
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
SOME FACTORS ALTERING THE SEVERITY OF ACUTE RADIATION PNEUMONITIS: VARIATION WITH CORTISONE, HEPARIN, AND ANTIBIOTICS
THE EFFECT OF IONIZING RADIATION, ADRENALECTOMY AND CORTISONE TREATMENT ON THE INTESTINAL ABSORPTION OF AMINO ACIDS