ANTIBODY SYNTHESIS AND THE RATIO OF PROTEIN FRACTIONS IN BLOOD SERUM UNDER THE INFLUENCE OF IONIZING RADIATION

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Biochemistry (U.S.S.R.) (English Translation)

OSTI ID:4171021

Prokopenko, L G

The study of immunogenesis in radiaiion sickness has become important in recent years Interest in this question is aroused because ionizing radiation. which destroys the natural protective mechanisms, may permit the development of infectious diseases which are often disastrous to the irradiated animal. Therefore. the study of the mechanism of inhibition of antibody production after irradiation becomes very valuable. The opinion exists that the synthesis of antibodies and some protein fractions of the blood occurs in the same cells of the reticuloendothelial system. A number of investigators consider the formation of antibodies as a modification of the synthesis of blood gamma -globulin in the presence of the antigen, since the antibcdy and the gamma -globulin are very similar in chemical and physicochemical properties such as the order of arrangement of amino acids, electrophoretic mobility, isoelectric point, etc. Immunization of animals by different antigens causes proliferation of the cells of the reticuloendothelial system and transformation of the lymphocytes into plasmatic cells; a number of authors consider this of major significance in the synthesis of specific and nonspecific blood globulins. This results from the repeatedly observed parallel increase in amount of globulins and titer of antibodies in immune animals. The effect of penetrating radiation on the ratio of protein fractions of blood serum has not been sufficiently studied. The literature contains only a few, contradictory results on this question. No work was found on the study of the combined action on antibody production and production of different protein fractions by two factors so antagonistic in antibody synthesis as immunization and penetrating radiation. It is therefore felt that it is not without interest to compare the dynamics of change in the synthesis of different antibodies and the ratio of protein fractions of blood serum. (auth)

• Research Organization: Kursk State Medical Inst., USSR
• NSA Number: NSA-14-012461
• OSTI ID: 4171021
• Journal Information: Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 24
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
AMINO ACIDS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
BLOOD SERUM
DISEASES
ELECTROPHORESIS
GLOBULINS
IMMUNITY
INFECTIONS
IRRADIATION
LYMPH SYSTEM
LYMPHOCYTES
PROTEINS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION SICKNESS
RADIATIONS
RETICULOENDOTHELIAL SYSTEM
TISSUES