Control of thymidine kinase synthesis in IHD vaccinia virus-infected thymidine kinase-deficient LM cells
Journal Article
·
· J. Virol., v. 16, no. 1, pp. 210-213
OSTI ID:4169836
The synthesis of vaccinia virus-induced thymidine kinase is normally arrested several hours after infection. In thymidine kinase-deficient LM cells infected with IHD strain of vaccinia virus, arrest occurs whether or not viral DNA synthesis is inhibited. With virus inactivated by uv irradiation, enzyme synthesis takes place, but arrest is abolished. It is suggested that an early viral genetic function is responsible for the cessation of thymidine kinase synthesis. (auth)
- Research Organization:
- Weizmann Inst. of Science, Rehovoth, Israel
- NSA Number:
- NSA-33-005709
- OSTI ID:
- 4169836
- Journal Information:
- J. Virol., v. 16, no. 1, pp. 210-213, Journal Name: J. Virol., v. 16, no. 1, pp. 210-213; ISSN JOVIA
- Country of Publication:
- United States
- Language:
- English
Similar Records
RADIOBIOLOGICAL STUDIES OF VACCINIA VIRUS AND ENCEPHALOMYOCARDITIS VIRUS
Dominant negative selection of vaccinia virus using a thymidine kinase/thymidylate kinase fusion gene and the prodrug azidothymidine
Host range restriction of vaccinia virus in Chinese hamster ovary cells: relationship to shutoff of protein synthesis. [Uv radiation]
Thesis/Dissertation
·
Mon Dec 31 23:00:00 EST 1962
·
OSTI ID:4099971
Dominant negative selection of vaccinia virus using a thymidine kinase/thymidylate kinase fusion gene and the prodrug azidothymidine
Journal Article
·
Tue Jul 05 00:00:00 EDT 2005
· Virology
·
OSTI ID:20726038
Host range restriction of vaccinia virus in Chinese hamster ovary cells: relationship to shutoff of protein synthesis. [Uv radiation]
Journal Article
·
Thu Nov 30 23:00:00 EST 1978
· J. Virol.; (United States)
·
OSTI ID:6452577
Related Subjects
*PHOSPHOTRANSFERASES-- BIOSYNTHESIS
*VACCINIA VIRUS-- BIOLOGICAL RADIATION EFFECTS
560131* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Microorganisms--Basic Studies
ANIMAL CELLS
INACTIVATION
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
ULTRAVIOLET RADIATION
*VACCINIA VIRUS-- BIOLOGICAL RADIATION EFFECTS
560131* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Microorganisms--Basic Studies
ANIMAL CELLS
INACTIVATION
N48310* --Life Sciences--Radiation Effects on Microorganisms- -Basic Studies
ULTRAVIOLET RADIATION