Hyperacute rejection of skin allografts in the mouse

Journal Article · Wed Oct 01 04:00:00 EDT 1975 · Transplantation, v. 20, no. 4, pp. 308-313

DOI:https://doi.org/10.1097/00007890-197510000-00007· OSTI ID:4168875

Gerlag, P G.G.; Koene, R A.P.; Hagemann, J F.H.M.; Wijdeveld, P G.A.B.

The destructive action of alloantiserum and exogenous complement on ingrowing skin allografts was studied. B6AF1 recipients of a B10.D2 skin graft received a single intravenous injection of B6AF1 anti-B10.D2 serum (antiserum to H-2K.31) together with rabbit complement (RC) within the first 10 days after transplantation. Different models were used: recipients without immunosuppression, recipients treated with antilymphocyte serum, x-irradiation, or enhancing antibody. If the injection was given between day 5 and 10 after grafting, hyperacute rejection occurred in all cases. The rejection seemed to be most violent when the injection was given on days 7 or 8. Injections given on days 1, 2, or 3 after grafting could not induce hyperacute rejection, but resulted, on the contrary, in a prolongation of graft survival, probably due to immunological enhancement. Injections on day 4 produced patchy necrosis, but the grafts recovered and the residual tissue showed a prolonged survival. The results suggest that the presence of a functioning vascular network is a prerequisite for the occurrence of hyperacute rejection of skin allografts in the mouse. (auth)

• Research Organization: Univ. of Nijmegen, Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-005795
• OSTI ID: 4168875
• Journal Information: Transplantation, v. 20, no. 4, pp. 308-313, Journal Name: Transplantation, v. 20, no. 4, pp. 308-313; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

*IMMUNE REACTIONS-- BIOLOGICAL RADIATION EFFECTS
*SKIN-- TRANSPLANTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
NECROSIS
X RADIATION