Selective lymphoid irradiation: III. Prolongation of cardiac xenografts and allografts in presensitized rats

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198203000-00006· OSTI ID:6703390

Hardy, M A; Oluwole, S; Fawwaz, R; Satake, K; Nowygrod, R; Reemtsma, K

Selective lymphoid irradiation (SLI) with palladium-109-hematoporphyrin (Pd-H) combined with antilymphocyte globulin (ALG) induces either donor-specific permanent rat heart allograft acceptance or significant allograft prolongation depending on the degree of donor-recipient matching. The purpose of this study was to determine if SLI combined with ALG can affect ACI heart allograft survival in Lewis recipients presensitized to ACI, and of hamster heart xenografts of Lewis rats. SLI combined with ALG delays allograft and xenograft rejection in the presence of induced or preformed antidonor antibodies, and converts primarily a humoral rejection into a cellular rejection by mechanisms as yet uncertain. Such peritransplant treatment had significant effect on the levels of antidonor complement-dependent cytotoxic antibody titers but did not correlate directly with graft survival. Histological analysis of rejected hearts in all groups demonstrated primarily a humoral hyperacute rejection in control animals and in recipients treated with ALG alone, while peritransplant treatment with Pd-H and ALG resulted not only in prolonged graft survival but histologically, primarily a cellular rejection of the graft. (JMT)

• Research Organization: Columbia Univ., New York, NY
• OSTI ID: 6703390
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 33:3; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560162* -- Radionuclide Effects
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& Toxicology-- Animals
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& Cells
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
GRAFTS
HAMSTERS
HEART
HEMATOPORPHYRINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PALLADIUM 109
PALLADIUM ISOTOPES
PARTIAL BODY IRRADIATION
PIGMENTS
PORPHYRINS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RATS
RODENTS
TRANSPLANTS
VERTEBRATES