Hypoxic sensitizers: radiobiological studies at the cellular level
Journal Article
·
· Radiology, v. 117, no. 2, pp. 453-457
The nitroimidazoles have been found to selectively sensitize hypoxic cells to the effects of irradiation. The latest in this family of drugs is RO-07- 0582, which is able to mimic 80 percent of the oxygen effect at a concentration of 5 mM by modifying the sensitivity of hypoxic cells to single doses of gamma rays; however, it is not a substitution for oxygen in promoting the repair of sublethal radiation damage between split doses. Studies show that it is a powerful cytotoxic agent as well and selectively operates against hypoxic cells. (auth)
- Research Organization:
- Columbia Univ., New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-33-000859
- OSTI ID:
- 4168059
- Journal Information:
- Radiology, v. 117, no. 2, pp. 453-457, Journal Name: Radiology, v. 117, no. 2, pp. 453-457; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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·
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· Radiat. Res.; (United States)
·
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Related Subjects
*ANIMAL CELLS-- RADIOSENSITIVITY
*OXYGEN-- RADIOSENSITIVITY EFFECTS
*RADIOSENSITIZERS-- PHARMACOLOGY
560121* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--External Source
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
DRUGS
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
RESPONSE MODIFYING FACTORS
TESTING
*OXYGEN-- RADIOSENSITIVITY EFFECTS
*RADIOSENSITIZERS-- PHARMACOLOGY
560121* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--External Source
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
DRUGS
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
RESPONSE MODIFYING FACTORS
TESTING