STUDIES ON RADIORESISTANCE. II. CHROMOSOME CONDITION AND RADIOSENSITIVITY OF A SUBLINE OF THE YOSHIDA SARCOMA INDUCED BY PREIRRADIATIONS
investigated in a subline of the Yoshida sarcoma induced by pre- irradiation. The subline, characterized by increased radiosensitivity, was found to be of mixed diploidhypotetraploid population. It has a modal chromosome number of 37 in earlier generations and 38 in latter generations in the diploid region, and of 70 to 73 in the tetraploid region. It was found that the polynloid cells showed a remarkable decrease in frequency during the serial transfers for 4 months without irradiation. There is a possibiliiy that the rise of the subline was induced by frequently repeated heavy s irradiations with an integral dose of 87,480 r during 94 generations. belationship between the chromosome number and radiosensitivity of the tumor is discussed. (auth)
- Research Organization:
- Sapporo Medical Coll.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-022767
- OSTI ID:
- 4167077
- Journal Information:
- Cytologia(Tokyo), Journal Name: Cytologia(Tokyo) Vol. Vol: 25
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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