RADIOSENSITIVITY OF YOSHIDA SARCOMA IN RATS AFTER X-IRRADIATION FOR SUCCESSIVE GENERATIONS. I. STUDY ON RADIO-RESISTANCE
An experiment was made to determine the degree of radioresistance in tumor cells after exposure for 27 months to 87480 r of x rays in 94 successive generations of Yoshida sarcoma. Whole body irradiation of 1000 r was given to rats with Yoshida sarcoma from the first to the 31st generation, and 2000 r each to those of the 32nd to 94th generation. In every case tumor cells were transplanted into the peritoneal cavity one hour after irradiation. Tumor cells of either the irradiated line or non-irradiated line were transplanted subcutaneously in the right shoulder of rats in order to measure the tumor regression of both lines following local exposure of 1000 r. After tumor cells were transplanted, the irradiated cells developed to three times the number of non-irradiated cells. The cure rate of subcutaneous transplanted tumor of the irradiated line was higher than that of the non-irradiated line. It is concluded that the irradiated line is more radiosensitive than the non-irradiated line. Some tumor stem cells may have undergone a certain type of mutational change after the repeated heavy successive irradiation. The mutant stem cells may be more radiosensitive than the original stem cells. (Abstr. Japan Med., 1: No.2, 1960)
- Research Organization:
- Sapporo Medical Coll.
- NSA Number:
- NSA-15-022079
- OSTI ID:
- 4045303
- Journal Information:
- Nippon Igaku Hoshasen Gaffai Zasshi, Journal Name: Nippon Igaku Hoshasen Gaffai Zasshi Vol. Vol: 19
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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