ACONITE-INDUCED VENTRICULAR TACHYCARDIA DURING RADIATION SICKNESS

Journal Article · Mon Oct 01 04:00:00 EDT 1962 · Actualites Cardiol. Angeiol. Intern.

OSTI ID:4165698

Jurkovic, V; Vokrouhlicky, L; Belobradek, Z

In order to study cardiac excitability and the effects of procaine, ventricular tachycardia was induced by intramyocardial injection of 0.05 ml 50% aconite solution in irradiated and nonirradiated rabbits of both sexes. Tracheotomy and thoracotomy were performed to facilitate access to the heart and to establish artificial respiration through a tracheal tube. Narcosis was induced by urethane. Electrocardiograms were made at various stages in both control and irradiated animals; the former showed no change in preliminary phases of the experiment. Procaine was administered by subcutaneous injection, bilateral vagosympathetic infiltration, or slow intravenous infusion. Its therapeutic effect was determined by giving it 5 min after trachycardia occurred, and its preventive action by giving it 5 min before. The x irradiation rate was 16.6 r/min, to a total dose of 1000 r. On the 3rd day after irradiation, the therapeutic effect of procaine after intramuscular injection was seen as a 50% normalization of heart action, with less by other routes of administration; its preventive effect was seen as a 58% normalization following slow intravenous infusion but was insignificant by other routes. Six days after irradiation, at the peak of radiation sickness, procaine's therapeutic and preventive actions had almost disappeared; its intravenous therapeutic application gave 25% normalization and its intramuscular preventive action provided 20% normalization of heart rate. However, on the 6th day, a profibrillatory effect was observed, especially in the therapeutic vagosympathetic infiltration technique and the preventive use by slow intravenous infusion. Suggested explanations of the reversal are: change in excitability of myocardium when it is irradiated, or change in effect of procaine when the whole organism is irradiated. Results favor the first explanation. (BBB)

• Research Organization: Second Medical Clinic, Hradek Kralove, Czech
• NSA Number: NSA-18-000054
• OSTI ID: 4165698
• Journal Information: Actualites Cardiol. Angeiol. Intern., Journal Name: Actualites Cardiol. Angeiol. Intern. Vol. Vol: 11
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ALKALOIDS
ANESTHESIA
BIOLOGY AND MEDICINE
CARBAMATES
DRUGS
ELECTRIC POTENTIAL
ELECTROCARDIOGRAPHY
ETHYL RADICALS
HEART
PHYSIOLOGY
PROCAINE
RABBITS
RADIATION DOSES
RADIATION SICKNESS
RECORDING SYSTEMS
SEX
SOLUTIONS
SURGERY
TOXICITY
URETHANE
X RADIATION