Measurement of serum ferritin by radioimmunoassay: results in normal individuals and patients with breast cancer

Journal Article · Wed Oct 01 04:00:00 EDT 1975 · J. Natl. Cancer Inst., v. 55, no. 4, pp. 791-795

OSTI ID:4163450

Marcus, D M; Zinberg, N

Ferritins are iron-containing proteins found in normal tissues; they increase in concentration in many tumors and the blood of tumor-bearing individuals. We utilized a double-antibody radioimmunoassay for measurement of serum ferritin and defined the upper limit of normal as 146 ng/ml for women (mean 34 ng/ml) and 193 ng/ml for men (mean 93 ng/ml). Serum ferritin levels exceeded these limits in preoperative sera of 41 percent of women with mammary carcinoma (mean 199 ng/ml) and in 67 percent of women with locally recurrent or metastatic mammary carcinoma (mean 671 ng/ml). Individuals with hepatic inflammatory states are known to have high serum ferritin, and ferritin was increased in 43 percent of patients with hepatitis or cirrhosis (mean 364 ng/ml) and in 13 percent of patients with ulcerative colitis or gastroduodenal ulcers (mean 106 ng/ml). Measurement of serum ferritin may be useful in evaluation of patients with breast cancer and in monitoring their response to therapy. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-33-003385
• OSTI ID: 4163450
• Journal Information: J. Natl. Cancer Inst., v. 55, no. 4, pp. 791-795, Journal Name: J. Natl. Cancer Inst., v. 55, no. 4, pp. 791-795; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

*FERRITIN-- RADIOIMMUNOASSAY
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NEOPLASMS
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TRACER TECHNIQUES