Radioimmunoassay of tumor markers in serum of patients with renal carcinoma
Having noted an increased serum level of TPA and CEA in patients with renal carcinoma the authors extended these studies by using a larger number of tumor markers. In 15 patients (11 men and 4 women after menopause) aged 33 to 74 years who had renal carcinoma, among them 3 with tumor metastases, the serum concentration of TPA, CA 12-5, CEA, AFP, ferritin, prolactin, ..beta..-HCG, and ..beta../sub 2/-microglobulin was measured by radioimmunoassay. Monoclonal antibodies were used in the determination of serum CA 12-5 and CEA. In all patients surgical treatment, irradiation, or cytostatic therapy had not been performed. In serum the normal range was exceeded by TPA in 7 patients, CA 12-5 in 3, CEA and AFP in one each, ferritin in 12, prolactin in 2, and ..beta../sub 2/-microglobulin in 10 patients. In one man serum prolactin was reduced. Serum ..beta..-HCG was normal in all patients. According to these results serum ferritin, TPA, and ..beta../sub 2/-microglobulin are of great value as tumor markers in patients with renal carcinoma. In several patients the increase of serum ..beta../sub 2/-microglobulin may be ascribed partly to deterioration of renal function. As no consistent patterns of tumor markers in serum were observed it is recommended to determine several tumor markers and not only one of them during the follow-up of patients. Radioimmunoassays for measuring the serum level of tumor markers, especially ferritin, TPA, and ..beta../sub 2/-microglobulin, may considerably assist in the management of patients with renal carcinoma by providing early information about tumor recurrence or metastases.
- Research Organization:
- Dept. of Nuclear Medicine, Academic Teaching Hospital, and Dept. of Urology, St.-Josefs-Hospital Krefeld-Uerdingen, Krefeld
- OSTI ID:
- 6932894
- Report Number(s):
- CONF-840619-; TRN: 87-008851
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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BIOLOGICAL MARKERS
RADIOIMMUNOASSAY
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AGE DEPENDENCE
FEMALES
FERRITIN
GLOBULINS
IMMUNE SERUMS
LTH
MALES
METASTASES
MONOCLONAL ANTIBODIES
PATIENTS
ANTIBODIES
BODY
COMPLEXES
DISEASES
GONADOTROPINS
HORMONES
IMMUNOASSAY
IMMUNOLOGY
IRON COMPLEXES
ISOTOPE APPLICATIONS
METALLOPROTEINS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
550601* - Medicine- Unsealed Radionuclides in Diagnostics