HISTOPATHOLOGICAL AND HEMATOLOGICAL STUDIES ON THE EARLY EFFECTS OF A SINGLE TOTAL BODY X-IRRADIATION ON THE HEMATOPOIESIS IN MICE, RATS AND GUINEA PIGS

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Proc. Inst. Nucl. Radiation Res. (Japan)

OSTI ID:4163167

Honda, Y

The effects of whole-body exposure to x radiation doses of 350 r in mice, 350 r in young rats, and 180 to 200 r in young guinea pigs on the blood picture were followed for 90 days following irradiation. Phosphorus-32 was used as a tracer in studies of spleen metabolism. Both medullary hematopoiesis in various bones and extramedullary hematopoiesis in the spleen were correlated with histological evidence of radiation injury. It was concluded that the increase in spleen weight beyond normal that was observed to reach a peak 20 days post- irradiation was due to the vigorous acceleration of extramedullary hematopoiesis. This response was considered to be compensatory in nature in view of the inadequacy of bone marrow hematopoiesis during this period, and it was concluded it was responsible for the sudden increase in neutrophils observed in peripheral blood at this time. (C.H.)

• Research Organization: Hiroshima Univ.
• NSA Number: NSA-18-000107
• OSTI ID: 4163167
• Journal Information: Proc. Inst. Nucl. Radiation Res. (Japan), Journal Name: Proc. Inst. Nucl. Radiation Res. (Japan) Vol. Vol: No. 2
• Country of Publication: Country unknown/Code not available
• Language: Japanese

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD
BLOOD FORMATION
BODY
BONE MARROW
GUINEA PIGS
LEUCOCYTES
METABOLISM
MICE
PHOSPHORUS 32
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RATS
SPLEEN
TRACER TECHNIQUES
X RADIATION