THE CONSEQUENCES OF THE CONTINUOUS INGESTION OF Sr$sup 90$ BY MICE
Two groups of mice are being maintained on food containing Sr/sup 90/. The first was placed on the special diet at 110 to 250 days of age, and this group produced the second, which has been exposed to Sr/sup 90/ since conception. Levels of dietary Sr/sup 90/ as high as 10 mu c/gm Ca did not adversely affect conception, parturition, or lactation. The median survival time of the dams maintained on this level of Sr/sup 90/ for 525 days, however, was reduced by about 17 per cent. Dams maintained on 5 mu c Sr/sup 90//gm Ca or less did not differ substantially from the control mice in survival time or in disease incidence during these 525 days. The median life span of mice exposed to 10 mu c Sr/sup 90//gm Ca since conception was reduced by about 41 per cent. A decrease in survival time was also apparent among the mice reared on 5.0, 2.5, and 1.0 mu c Sr/sup 90//gm Ca. Tumors that can be attributed to radiation have appeared only among those mice maintained throughout life on 10 mu c Sr/sup 90//gm Ca. Besides an increase over the normal incidence of tumors of the bloodforming tissues, there have been epidermoid carcinomas of the oral cavity, osteolytic tumors of the skeleton, and osteogenic sarcomas. The osteogenic sarcomas appeared much later and in much smaller number than had been expected on the basis of previous experience with mice that had been injected with Sr/sup 90/. Since the major difference between a single injection and continuous ingestion concerns the dose rate, it appears that the amount of radiation absorbed per unit time is an important factor in the neoplastic process. In addition, the delay in the appearance of osteogenic sarcomas until the mice were approximately 450 days old suggests that very young mice are not necessarily more sensitive to a radiocai-cinogenic stimulus than adult mice. (auth)
- Research Organization:
- Argonne National Lab., Lemont, Ill.
- NSA Number:
- NSA-14-010368
- OSTI ID:
- 4157873
- Journal Information:
- Radiology (U.S.), Journal Name: Radiology (U.S.) Vol. Vol: 74; ISSN RADLA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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AGE-- CALCIUM-- DIET-- DISEASES-- FOOD-- GLANDS-- MAMMARY GLANDS-- MICE-- PHYSIOLOGY-- PREGNANCY-- QUANTITY RATIO-- RADIATION DOSES- - RADIATION EFFECTS-- REPRODUCTION-- STOMACH-- STRONTIUM 90-- SURVIVAL TIME
BIOLOGY AND MEDICINE