RADIOPROTECTIVE EFFECTS OF CYSTEAMINE ON PERIPHERAL BLOOD PICTURE OF ALBINO RATS

Journal Article · Thu Oct 01 04:00:00 EDT 1959 · Radiobiol. Latina

OSTI ID:4153344

Nuvolone, U

The changes in the peripheral blood of albino rats panirradiated with 600 r and protected with cysteamine ( beta mercaptoethylamine) in different doses administered in different x-ays were studied. Cysteamine protects against the blood changes only if given in the right dose (3 mg) intraperitoneally, immediately before irradiation. If administered 6 hr before irradiation it has no immediate protective action, but it enhances the recovery of hematopoiesis by protecting the recovery factor. Pretreatment during the days preceding irradiation appears to be useless and becomes harmful if continued after irradiation. Cysteamine injected into normal animals in total doses exceeding 48 mg (two 3 mg doses pro die 150 mg/kilo) causes leucopenia characterized by relative granulocytosis and lymphopenia. Cysteamine is thus shown to have a radiomimetic action on blood cells. (auth)

• Research Organization: Universita, Messina, Italy
• NSA Number: NSA-14-024030
• OSTI ID: 4153344
• Journal Information: Radiobiol. Latina, Journal Name: Radiobiol. Latina Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

AMINES
ANEMIA
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD
BLOOD FORMATION
BODY
CYSTEAMINE
DIFFUSION
DRUGS
INTESTINE
IRRADIATION
MEA
MEDICINE
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
RECOVERY
TOXICITY
VARIATIONS