WEIGHT VARIATION OF ORGANS OF ALBINO RATS WHOLE-BODY IRRADIATED AND PROTECTED WITH DOSES AND DIFFERENT TREATMENTS OF CYSTEAMINE

Journal Article · Thu Oct 01 04:00:00 EDT 1959 · Radiobiol. Latina

OSTI ID:4146615

Nuvolone, U; Tognacca, M L

A study was made of changes in body weight and in the weight of heart, liver, spleen, kidney, adrenal glands, and testis in normal albino rats treated with high doses of cysteamine and in rats protected with different doses of cysteamine administered in different ways before 600 r whole body irradiation. Prolonged administration of cysteamine inhibits growth of body weight, which is resumed immediately after treatment is stopped. A retardation of the resumption of growth in body weight was observed in irradiated animals protected with 3 mg of cysteamine before irradiation; in the case of animals treated for 8 days (6 mg pro die in two doses) before irradiation the resumption of growth was slower. Prolonged treatment with cysteamine did not produce detectable weight changes in the heart, liver, or testes; but a considerable weight loss occurred in the spleen and adrenals. Administration of a single 3-mg dose 15 min before irradiation protected the spleen and the adrenals in different ways and by different mechanisms. (auth)

• Research Organization: Universita, Messina, Italy
• NSA Number: NSA-14-023982
• OSTI ID: 4146615
• Journal Information: Radiobiol. Latina, Journal Name: Radiobiol. Latina Vol. Vol: 2
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

ADRENAL GLANDS
AMINES
BIOLOGY AND MEDICINE
BODY
CYSTEAMINE
EFFICIENCY
ETHYL RADICALS
GONADS
HEART
IRRADIATION
KIDNEYS
LIVER
MEA
MEDICINE
ORGANIC SULFUR COMPOUNDS
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RATS
SPLEEN
TESTING
TISSUES
VARIATIONS
WEIGHT