THE MECHANISM OF UNCOUPLING OF OXIDATIVE PHOSPHORYLATION IN RAT SPLEEN AND LIVER MITOCHONDRIA AFTER WHOLE-BODY IRRADIATION
Data are presented which show that whole-body irradiation of 800 r depresses the P: 0 ratio of mitochondria isolated from spleen and liver 24 hours after radiation. The action of the radiation is shown to be indirect. These data indicate that the mode of action is activation of the pituitary, with subsequent activation of the thyroid and the adrenal cortex. Inactivation of the spleen-phosphorylating mechanism is the result of overproduction of thyroxine; inactivation of the liver-phosphorylating mechanism is the result of overproduction of adrenal cortical steroids. The mechanism of action and the specificity of action are discussed in relation to the radiosensitivity of the spleen and the liver and the degree of radiation protection which they afford. (auth)
- Research Organization:
- Amherst Coll., Mass.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-016565
- OSTI ID:
- 4153060
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 12
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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