RESTITUTION OF LIVER MITOCHONDRIA IN WHOLE-BODY IRRADIATED MICE
Journal Article
·
· Sci. Sinica (Peking)
OSTI ID:4150739
Characteristics of swelling, the degree of coupling of oxidative phosphorylation-respiratory control, and P/O ratios of mitochondria in early post- irradiation stages were examined. White male mice were given a dose of 700 r x rays and killed 30 minutes, 1 hour, and 4 hours after exposure. Spontaneous swelling of liver mitochondria 30 minutes and 1 hour after exposure is markedly increased: an essentially normal condition if found at 4 hours. Contrasting of these results with those from thyroxine or Ca/sup 2+/-induced swelling, it is suggested that a slight alteration in structural integrity is involved in the early post-irradiation stage. The respiratory control index of mitochondria falls off 30 min after exposure and reaches a minimum 1 hour post-irradiation. A slight depression of P/O ratios appears only 1 hour after irradiation. Nearly complete or complete recovery of both respiratory control index and P/O ratio is achieved by 4 hours. Parallel with the biochemical lesion are the decrease and subsequent increase in the protein content of the mitochondrial suspension per gram of fresh liver tissue. From the results of this study and the electronmicroscopic observations of Mochituk, it appears that the mitochondria of mouse liver are transiently damaged both structurally and functionally in vivo, but are soon restituted to reach pre-irradiation levels. (H.M.G)
- Research Organization:
- Inst. of Biophysics, Academia Sinica, Peking
- NSA Number:
- NSA-18-001429
- OSTI ID:
- 4150739
- Journal Information:
- Sci. Sinica (Peking), Journal Name: Sci. Sinica (Peking) Vol. Vol: 12
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Effects of x irradiation on respiratory control and P/O ratio in isolated rat liver mitochondria having different respiratory control ratios
In vitro effects of microwave radiation on rat liver mitochondria
Quantitative changes in rat liver mitochondria following whole body irradiation
Journal Article
·
Sat May 01 00:00:00 EDT 1976
· Radiat. Res.; (United States)
·
OSTI ID:7362331
In vitro effects of microwave radiation on rat liver mitochondria
Journal Article
·
Sat Dec 31 23:00:00 EST 1983
· Bioelectromagnetics (N.Y.); (United States)
·
OSTI ID:7188369
Quantitative changes in rat liver mitochondria following whole body irradiation
Journal Article
·
Wed Dec 31 23:00:00 EST 1958
· Experimental Cell Research
·
OSTI ID:4277394