THE BROMIDE SPACE AFTER THE INTRAVENOUS ADMINISTRATION OF $sup 82$Br
After the intravenous administration of Br/sup 82/ in man, the isotope was completely distributed after 2 hr and the volume of distribution remained stable for at least 12 hr. A selectively high concentration of Br/sup 82/ in the gastric contents was confirmed. An average of 20% of the administered dose was secreted into the stomach in 12 hr. If allowance was made for this dose loss into the stomach, in addition to that lost in the urine, the extracellular fluid volume determined by this method represented 22.6% of the ideal body weight and the correlation between the two is closer than when the loss of isotope into the stomach is unknown. It is suggested that the intravenous administration of Br/ sup 82/ is a rapid and accurate method for measuring the extracellular fluid volume, provided that the gastric loss of isotope over the period of equilibration is known. (auth)
- Research Organization:
- Middlesex Hospital, London
- NSA Number:
- NSA-18-001356
- OSTI ID:
- 4151903
- Journal Information:
- Journal of Nuclear Medicine (U.S.), Journal Name: Journal of Nuclear Medicine (U.S.) Vol. Vol: 4; ISSN JNMEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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