ISLET CELL TUMORS OF THE PANCREAS IN THE IRRADIATED AND NON-IRRADIATED RAT
Technical Report
·
OSTI ID:4150380
During a study of the long-term effects of ionizing radiation on the rat a large number of animals with pancreatic neoplasms was found. Morphologically, the tumors resemble giant islets of Langerhans and were composed predominantly of beta cells. Approximately half of the tumors showed some degree of capsular invasion. The incidence of pancreatic islet cell tumors among non-irradiated control animals was 9.8%, whereas the average incidence in animals from the same litters but subjected to total-body x irradiation with doses of 430 or 680 rads was 18%. The incidence of this tumor in either control or irradiated groups is higher than that reported in any previous reference in the literature. The problem of histogenesis and possible relationships to other endocrine tumors are discussed. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-14-017696
- OSTI ID:
- 4150380
- Report Number(s):
- USNRDL-TR-420
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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