PANCREATIC ISLET CELL TUMORS AND RENAL TUMORS IN THE MALE RAT FOLLOWING NEUTRON EXPOSURE
During a study of the long term and late effects of fast neutron exposure in the rat, a large number of primary pancreatic and renal neoplasms were observed at autopsy. The incidence of pancreatic islet cell tumors among nonirradiated control animals was 17% whereas the same tumor was found in 56% of the animals exposed to 230 rads and 44% of those exposed to 320 rads. The functional significance, if any, of these tumors was not established. Most of the animals with islet cell tumors also had primary tumors in one or more of the other endocrine tissues although no specific pattern of concomitant tumors was discernible. Renal neoplasms, in the form of adenomas, carcinomas and transitional cell carcinomas, were found in 41% of the animals exposed to 230 rads and in 43% of those exposed to 320 rads. No renal neoplasia was observed in the non-irradiated controls derived from the same litters. This finding suggests that renal neoplasia in these rats is a response to radiation rather than an event in the normal aging process. On a rad dose basis, neutrons are more potent than x rays for the induction of both islet cell and renal parenchymal tumors. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-16-000049
- OSTI ID:
- 4834165
- Report Number(s):
- USNRDL-TR-529
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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