THE RADIOPROTECTIVE EFFECT OF A CYSTEAMINE-CYSTAMINE-GLUTATHIONE SYSTEM. ANATOMICAL-FUNCTIONAL INVESTIGATION ON THE BONE MARROW AND PERIPHERAL BLOOD

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Radiobiol., radioterap. e fis. med.

OSTI ID:4150208

Rondanelli, E G; Gorini, P; Trenta, A; Fiori, G P

In a study of the radioprotective effects of a system of cystamine, cysteamine, glutathione, vitamin B/sub 6/, vitamin C, and glucuronolactone on the biological activity of the bone marrow and the peripheral blood, thirty patients (ten with pulmonary carcinoma, ten with uterine carcinomas, and ten with larynx carcinomas) treated with x radiation were investigated. Systematic hematological studies were made on all the patients before the irradiation, at the end of the therapy, and thirty days later. In patients receiving the radioprotective preparation the state of myelocitopenia following x-ray therapy was less marked than in the controls even immediately after the end of the irradiation. The proliferative activity of the erythroblasts and granuloblasts was less concentrated in patients with radioproblast and granuloblast series shows that the alteration of this activity as a result of the radiation is less in patients receiving the cysteamine system. The results obtained in the myelological investigation shows a rigid parallelism with peripheral hemochromocytometric evidence. This indicates that the preparation has a protective effect on the basic biological activity of the myeloid cells, increases the functional renewal, and gives protection at the blood platelet level of the peripheral blood. (tr- auth)

• Research Organization: Universita, Pavia, Italy
• NSA Number: NSA-14-017768
• OSTI ID: 4150208
• Journal Information: Radiobiol., radioterap. e fis. med., Journal Name: Radiobiol., radioterap. e fis. med. Vol. Vol: (3) 15
• Country of Publication: Country unknown/Code not available
• Language: Italian

Related Subjects

AMINO ACIDS
ANEMIA
BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BODY
BONE MARROW
CANCER
CHEMICAL REACTIONS
CYSTAMINE
CYSTEAMINE
ERYTHROCYTES
LEUCOCYTES
LEUKEMIA
LUNGS
MAN
MEA
MEDICINE
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDATION
PLATELETS
RADIATION EFFECTS
RADIATION PROTECTION
RADIOTHERAPY
REDUCTION
SEX
STANDARDS
TISSUES
TUMORS
UTERUS
VITAMIN B-6
VITAMIN C
VITAMINS
X RADIATION