Age response for line CHO Chinese hamster cells exposed to x irradiation and alpha particles from plutonium

Journal Article · Mon Sep 01 04:00:00 EDT 1975 · Radiat. Res., v. 63, no. 3, pp. 422-433

DOI:https://doi.org/10.2307/3574094· OSTI ID:4149421

Raju, M R; Tobey, R A; Jett, J H; Walters, R A

The age response of Chinese hamster cells (line CHO) synchronized by mitotic selection and by mitotic selection with hydroxyurea resynchronization was studied for x rays and alpha particles from plutonium of 4.4-MeV residual energy. The age response for alpha particles when mitotically synchronized cells are used indicated that cells in S are slightly more sensitive but that the magnitude of variation is quite small. When cells were synchronized first by mitotic selection and then resynchronized by hydroxyurea, the variation of radiosensitivity as a function of cell cycle for x rays was found to be enhanced because of a higher degree of synchrony. In the case of alpha particles, it was found that cells in late S were more sensitive and that there was a clear peak of resistance corresponding to cells in G$sub 2$/early G$sub 1$. (auth)

• Research Organization: Los Alamos Scientific Lab., NM
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-007430
• OSTI ID: 4149421
• Journal Information: Radiat. Res., v. 63, no. 3, pp. 422-433, Journal Name: Radiat. Res., v. 63, no. 3, pp. 422-433; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- BIOLOGICAL RADIATION EFFECTS
*CELL CYCLE-- RADIOSENSITIVITY EFFECTS
*RADIOSENSITIVITY-- AGE DEPENDENCE
560121* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--External Source
ALPHA PARTICLES
CELL CULTURES
HAMSTERS
HYDROXY COMPOUNDS
IRRADIATION
LET
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
PLUTONIUM 238
SURVIVAL CURVES
SURVIVAL TIME
SYNCHRONOUS CULTURES
UREA
X RADIATION