STUDY OF DELAYED MORTALITY, LYMPHOID REGENERATION, AND IMMUNOLOGICAL REACTIVITY OF IRRADIATED THYMOPRIVIC MICE RESTORED BY FETAL LIVER, BONE MARROW, OR ISOGENIC SPLEEN (in French)
Journal Article
·
· Compt. Rend. Soc. Biol.
OSTI ID:4145286
The effects of fetal liver, medullary, or splenlc cells on the lymphoid restoration and the recovery of the immunological functions in irradiated thymoprivic adult mice were compared. Male and female mice were subjected to a thymectomy or a simulated thymectomy at the age of 35 to 40 days. These mice, together with a control group, were then exposed at the age of 50 to 75 days to wholebody x irradiation of 870 r. Each group was then subdivided into three groups: one group received and intravenous injection of fetal liver, bone marrow, or splenic cells. The study of the mortality showed that during the 30-day period following the irradiation, the immediate mortality was the same in all the animals. The thymoprivic mice treated with fetal liver had a particular behavior. They had characteristic secondary ilinesses, although the restoration was isogenic. The lymphoid regeneration, in particular that of the small lymphosytes, was deficient. Sixty days after the irradiation, there was no evidence of active immunological cells in the spleen of the mice receiving fetal liver. This can be attributed to the fact that the fetal liver contains a very small number of mature lymphoid cells and the immature cells can not attain, in the absence of the thymus, a stage of their evolution that permits the normal functions of lymphoid cells to be fulfilled. (J.S.R.)
- Research Organization:
- Institut du Radium, Paris
- NSA Number:
- NSA-18-005035
- OSTI ID:
- 4145286
- Journal Information:
- Compt. Rend. Soc. Biol., Journal Name: Compt. Rend. Soc. Biol. Vol. Vol: 157
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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