SURVIVAL OF GUINEA PIGS AFTER LETHAL IRRADIATION AND HOMOLOGOUS BONE MARROW INJECTIONS
The lethal effect of whole-body x irradiation was studied in a group of 288 heterozygous English short-haired male albino guinea pigs. These animals received graded doses of 450, 600, 675, 750, 825, or 900 r. The LD/sub 100(15)/ days was found to be 675 r. By using homologous bone-marrow transfusions after lethal whole-body irradiation in 168 guinea pigs, by doses ranging from 675 to 900 r, a 30-day survival of 12 to 21% (median 18.5%) was achieved. This heterozygous group of guinea pigs in general was unable to survive skin homografts from the donor of the bone marrow immediately after whole-body x irradiation. However, in the two animals surviving these three procedures for several weeks, the skin homografts also survived. (auth)
- Research Organization:
- New York Univ. Post-Graduate Medical School, New York; University Hospital, New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-023981
- OSTI ID:
- 4145031
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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