ERYTHROPOIETIC RECOVERY MEASURED BY Fe$sup 59$ UPTAKE IN IRRADIATED MICE PROTECTED WITH BONE MARROW

Journal Article · Fri Jul 01 00:00:00 EDT 1960 · Proc. Soc. Exptl. Biol. Med.

OSTI ID:4141783

Mirand, E A; Hoffman, J G; Prentice, T C

Twenty-four hour uptake of Fe/sup 59/ was used as quick measure of erythropoiesis in Swiss male mice. In normal nonirradiated mice, iron uptake is not affected by intravenous injection of isologous, homologous, and heterologous bone marrow cells except for inocula greater than 40 x 10/sup 6/ cells. Injection of these cell types after 900 r whole-body x radiation increases Fe/sup 59/ uptake rates in the order: heterologous, homologous, isologous. Protection against lethal radiation effect as measured by survival and Fe/sup 59/ uptake depended on genetic relationship between bone marrow, donor, and recipient. (auth)

• Research Organization: Roswell Park Memorial Inst., Buffalo; Univ. of Buffalo
• NSA Number: NSA-14-018785
• OSTI ID: 4141783
• Journal Information: Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 104
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BLOOD FORMATION
BODY
BONE MARROW
DIFFUSION
ERYTHROCYTES
IMMUNITY
IRON 59
IRRADIATION
LETHAL DOSE
MEASURED VALUES
METABOLISM
MICE
RADIATION DOSES
RADIATION PROTECTION
RADIATION SICKNESS
RECOVERY
SURVIVAL TIME
X RADIATION