EFFECT OF SEGMENTAL GUT SHIELDING ON MORTALITY FROM INTESTINAL RADIATION
An experimental method for the isolation of a segment of ileum with vascular supply intact and re-establishment of the continuity of the gut by end- to-end anastamosis in rats is described. Shielding a segment of ileum in continuity with the rest of the small intestine provided protection from radiation of the abdomen with 1000 r; shielding a segment of isolated ileum did not. The beneficial effect of segmental gut shielding in the intestinal radiation syndrome is dependent on the shielded part being in continuity with the intact ileum. The mechanism of the protective effect of th shielding procedure is probably the reabsorption of fluid and electrolytes through the intact mucosa of the shielded part. No evidence of a protective mechanism independent of the physiologic absorptive function of the shielded part was revealed. Treatment of the intestinal radiation syndrome may depend principally on the restoration of fluid and electrolyte balance during the critical period while the injured mucosa undergoes repair. (auth)
- Research Organization:
- Western Reserve Univ., Cleveland. Atomic Energy Medical Research Project
- DOE Contract Number:
- W-31-109-ENG-78
- NSA Number:
- NSA-14-014655
- OSTI ID:
- 4140777
- Report Number(s):
- NYO-2064
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-60
- Country of Publication:
- United States
- Language:
- English
Similar Records
PROTECTION AGAINST LETHAL EFFECTS OF INTESTINAL RADIATION BY SURGICAL ISOLATION OF THE IRRADIATED SEGMENT
ANNUAL REPORT FOR PERIOD ENDING JUNE 30, 1960