LONG-TERM EFFECTS OF X-IRRADIATION AND AGING IN THE SKIN OF MICE
The skin of mice aged two weeks to 30 inonths was utilized in an aging study. Aging symptoms were compared with characteristics of irradiated skin; comparisons were inade during the period between one day and 18 months after small skin areas received 500, 1000, or 3000 r of x rays as a single dose, or after a 500 r systemic exposure. Certain age-dependent alterations in skin structure and function involved hair growth. The number of hair-producing follicles per square millimeter decreased with increasing age. This is primarily due to a loss of normal follicle organization, although changes in body weight do influence density. A lengthening of the time period between plucking and the cessation of all hair growth in an area became evident with increasing age of the animal. Histological preparations demonstrated an asynchronism in the population of follicles, the actual growth tiine of individual follicles probably remaining constant. The area of skin responding with hair growth, relative to the area plucked, decreased with age, perhaps reflecting a change in the growth threshold properties of the skin. The frequency of the appearance of bald spots increased with age. This condition is considered an abnorinal consequence of aging, however, because hair loss is mediated by a histopathological disruption of follicles during the hair growth period. (TCO)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-18-003574
- OSTI ID:
- 4139984
- Resource Relation:
- Other Information: Thesis. Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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