EXPERIMENTAL STUDIES ON THE FRACTIONAL IRRADIATION OF RABBIT SKIN

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4068254

Yamamoto, N

The shaved skin of rabbits were irradiated with daily doses of 300 r and irradiations were continued until 1500 r to 9000 r in total had been given. Macroscopic and microscopic observations showed early erythema developed in every case, 5 to 6 days from the beginning of irradiation. This erythema faded in 10 to 16 days even in the cases to which irradiation was being continued. Main erythema became manifest when more than 3000 r had been administered. Its time of appearance and duration was proportional to the dose administered. Epilation and baldness occurred over 3000 r and 6000 r, respectively. These findings coresponded to the histological change of hair follicles. The excoriation was different in nature within their border line in the vicinity of 4500 r. Acute erosion occurred in the case of irradiation of more than 6000 r and its findings were well in accordance macroscopically and microscopically. Up to 3000 r, hair was able to recover completely, but permanent baldness occurred over 7500 r. Recovery of epidermis had taken place below 6000 r when examined histologically, thickening at 7500 r and chronic ulceration in more than 7500 r were found. It was noteworthy that almost all of these findings coincided both macroscopically and microscopically. (Absts. Japan. Med., 1: No. 7, 1960.)

• Research Organization: Showa Medical Coll., Japan
• NSA Number: NSA-15-022112
• OSTI ID: 4068254
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
HAIR
IRRADIATION
RABBITS
RADIATION DOSES
RADIATION INJURIES
RECOVERY
SKIN