THE EFFECT OF ACRYLAMIDE AND OF ITS HYDROGENATED DERIVATIVE ON IRRADIATED BIOLOGICAL SYSTEMS (in Russian)
The effect of an aqueous solution of acrylamide CH/sub 2/ = tive, propionic acid amide CH/sub 3/ --CH/sub 2/--CONH/sub 2/, on the degree of grafting of a polymer to irradiated wheat seeds (Triticum vulgare), on the survival of irradiated diploid yeast cells (Saccharomyces vini, strain of Megri- 139B), and on the degree of hemolysis of irradiated human erythrocytes. The acrylamide grafted readily to the irradiated wheat seeds, but propionic acid amide CH/sub 3/ --CH/sub 2/--CONH/sub 2/ did not polymerize in the presence of the irradiated wheat seeds. Similarly, treatment of irradiated yeast cells with a 1% solution of acrylamide increased the survival of the yeast cells, while treatment with a solution of propionic acid amide decreased the survival of yeast cells as compared to the survival of the control yeast cells. A concentration of 0.03 to 0.25 wt.% of acrylamide in a suspension of human erythrocyte cells given a dose of 80 kr resulted in a resistance to hemolysis after incubation of the cells at 5 deg C for a period of 24 hours. The propionic acid amide caused a sharp increase in hemolysis on the irradiated and unirradiated erythrocytes. It is concluded that an unsaturated, low-molecular-weight substance which is readily polymerized can react with free radicals which are formed as a result of irradiation. (TTT)
- Research Organization:
- Moscow State Univ.
- NSA Number:
- NSA-18-003586
- OSTI ID:
- 4132504
- Journal Information:
- Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals, Journal Name: Doklady Akademii Nauk SSSR (U.S.S.R.) English translation currently published in a number of subject-oriented journals Vol. Vol: 152; ISSN DANKA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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