RADIATION-INDUCED OSTEOGENIC SARCOMA IN PARABIONT RATS

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Laboratory Investigation (U.S.)

OSTI ID:4132456

Warren, S; Chute, R N

Studies were made on the development of osteogenic sarcomas in irradiated rats. Parabiosis and shielding of one partner permitted the other to survive a supralethal single dose of 1000 r of whole body x irradiation and to live to develop late complications. Parabiosis increased the incidence of osteogenic sarcoma in rats. Parabiosis and external whole-body radiation produced osteogenic sarcomas, sometimes multiple, in about 5% of the rats. Most osteogenic sarcomas produced were endosteal in origin. Osteogenic sarcomas varied widely in individually averaged increments of diameter, from 1.1 to 0.07 mm per day. Abnormalities of parathyroid glands were present but did not correlate with occurrence of osteogenic sarcomas. (P.C.H.)

• Research Organization: New England Deaconess Hospital, Boston
• NSA Number: NSA-18-008169
• OSTI ID: 4132456
• Report Number(s): TID-18787; 0023-6837
• Journal Information: Laboratory Investigation (U.S.), Journal Name: Laboratory Investigation (U.S.) Vol. Vol: 12; ISSN LAINA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD CIRCULATION
BODY
BONES
CARCINOGENESIS
GLANDS
PARABIOSIS
PARATHYROIDS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SARCOMAS
SHIELDING
SURVIVAL TIME
VARIATIONS
VOLUME
X RADIATION