Value of radioimmuno-assay of triiodothyronine and thyrotropic hormone in the diagnosis of thyroid disease

Journal Article · Tue Apr 01 00:00:00 EDT 1975 · Dtsch. Med. Wochenschr., v. 100, no. 15, pp. 805-812

OSTI ID:4132365

Hesch, R D; Emrich, D; von zur Muehlen, A; Breuel, H P; Goettingen, U

Results of a purely in-vitro test were compared with previously available methods in 425 patients. For triiodothyronine, a normal range must be differentiated from the so-called euthyroid range (0.8-2.0 ng/ml) for patients with euthyroid goitre. The accuracy for triiodothyronine is then more than 95% and in hyperthyroidism 97.5%. It is, therefore, superior to other in-vitro measurements. But a disadvantage is that it is easily influenced by thyroid and extrathyroid factors. Similar accuracy is obtained for the TRH function test (thyrotropine-releasing hormone). Notable is a 'negative' TRH test in 20% of patients with euthyroid goitre. The significance of triiodothyronine determination is decreased in autonomous adenoma, in which the TRH test has an accuracy of 96.5%. In rare diseases of the thyroid all diagnostic possibilities must be taken into account. In ordinary practice a stepwise course is suggested. RT$sub 3$U, T$sub 4$, T$sub 3$ and thyroid scan with sup(99m)Tc pertechnetate are useful as basic tests. PBI is still thought to be important. The second step involves the TRH test rather than $sup 131$I function test. Triiodothyronine determination is best for therapeutic and follow-up purposes, a situation in which TRH test is of limited value. (orig.)

• Research Organization: Goettingen Univ. (F.R. Germany). Medizinische Klinik und Poliklinik; (F.R. Germany). Radiologische Klinik und Poliklinik
• NSA Number: NSA-33-009679
• OSTI ID: 4132365
• Journal Information: Dtsch. Med. Wochenschr., v. 100, no. 15, pp. 805-812, Other Information: 5 tabs.; 21 refs. Orig. Receipt Date: 30-JUN-76
• Country of Publication: Germany
• Language: German

Related Subjects

N48830* -Life Sciences-New Tracer Techniques-Other
550601* -Biomedical Sciences
Basic Studies-Medicine- Unsealed Radionuclides in Diagnostics
*ENDOCRINE DISEASES- DIAGNOSIS
*HYPERTHYROIDISM- DIAGNOSIS
*HYPOTHYROIDISM- DIAGNOSIS
*SCINTISCANNING- TECHNETIUM 99
*THYROID- SCINTISCANNING
*TRH- RADIOIMMUNOASSAY
*TRIIODOTHYRONINE- RADIOIMMUNOASSAY
IODINE 131
ISOMERIC NUCLEI
NUCLEAR MEDICINE
PATIENTS
PBI
PERTECHNETATES
THYRONINE
THYROXINE
TSH