SELF-DECOMPOSITION OF COMPOUNDS LABELLED WITH RADIOACTIVE ISOTOPES
The decomposition of an isotopically labeled compound may result from: (1) primary (internal) radiation effect. i.e., the decomposition or transformation of a molecule caused by the disintegration of one of its unstable nuclei; (1) primary (external) radiation effect, i.e., the decomposition or transformation of a molecule by interactions with nuclear particles; (3) secondary rsdiation effects, i.e., the decomposition or transformation of a molecule of the labeled compound because of its reaction with reactive species. e.g., free radicals from primary radiation decomposition; and (4) chemical effect, i.e., the decomposition or transformation of the radioactive material caused by chemical reactions not connected with radiation. The magnitude of the radiation effects caused by the decomposition is described. Remedial measures are suggested for the different types of decomposition. The stabilities of uniformly labeled (C/sup 14/)-sucrose and D-(C/sup 14/) glucose samples with relatively high specific radioactivities are tabulated. The methods employed in determining the magnitude of the radiation effects for macromolecules are described. (B.O.G.)
- Research Organization:
- Radiochemical Centre, Amersham, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-002669
- OSTI ID:
- 4130894
- Journal Information:
- Nature, Journal Name: Nature Vol. Vol: 188
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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