Metronidazole: effect on radiosensitivity of tumor and normal tissues in mice

Journal Article · Sat Nov 01 04:00:00 EST 1975 · J. Natl. Cancer Inst., v. 55, no. 5, pp. 1189-1194

OSTI ID:4130535

Stone, H B; Withers, H R

Local control of a mammary carcinoma in air-breathing C3H mice was enhanced by giving metronidazole before radiotherapy. When 0.5 to 1.0 Mg metronidazole/g body weight was given ip 10 minutes before irradiation, the dose required for local control of 50 percent of the tumors (TCD50) was reduced by a factor of 1.37 to 1.38. The TCD50 was reduced by a factor of 1.48 to 1.50 when tumors were irradiated 30 to 60 minutes after 1.0 mg/g. Metronidazole alone, at a dose of 1.0 mg/g, only slightly inhibited tumor growth. The acute skin response of the leg, as determined by the radiation dose required to produce complete moist desquamation in 50 percent of the animals (DD50), was enhanced by a factor of 1.26 when mice were irradiated 10 minutes after a dose of 1.0 mg metronidazole/g. Clonogenic cells in the jejunal epithelium were not sensitized after metronidazole administration in either air-breathing mice or those irradiated in O$sub 2$ 30 pounds per square inch, but the drug appeared to exert a slight protective effect at higher doses of radiation. (auth)

• Research Organization: Univ. of Texas, Houston
• NSA Number: NSA-33-009557
• OSTI ID: 4130535
• Journal Information: J. Natl. Cancer Inst., v. 55, no. 5, pp. 1189-1194, Journal Name: J. Natl. Cancer Inst., v. 55, no. 5, pp. 1189-1194; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

*INTESTINES-- RADIOSENSITIVITY
*METRONIDAZOLE-- RADIOSENSITIVITY EFFECTS
*SKIN-- RADIOSENSITIVITY
*TUMOR CELLS-- RADIOSENSITIVITY
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
ANOXIA
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
GAMMA RADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
OXYGEN
PARTIAL BODY IRRADIATION
WHOLE-BODY IRRADIATION