Effect of metronidazole on the radiocurability and oxygenation of the C3HBA tumor

Journal Article · Fri Oct 01 04:00:00 EDT 1976 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574548· OSTI ID:7332294

Haynes, M J; Inch, W R

Oxygen diffusion current was measured in the C3HBA mammary adenocarcinoma with a platinum microelectrode. An intraperitoneal injection of 0.6 mg/g body weight of metronidazole caused an increase in the oxygen diffusion current of roughly two and one-half times within 60 min after injection. The same tumor was also found to be more radiosensitive when metronidazole was given prior to treatment with x rays. The TCD/sub 50/'s at 60 days after treatment were reduced by factors of 1.32 and 1.35 if the animals were injected with 0.6 and 0.3 mg/g, respectively, of metronidazole 30 min prior to irradiation. The higher dose of 0.6 mg/g was more effective than 0.3 mg/g at both 4000 and 5000 rad of x rays as determined by the number of tumor cures at 90 days after treatment.

• Research Organization: Ontario Cancer Treatment and Research Foundation, London
• OSTI ID: 7332294
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 68:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
AZOLES
CARCINOMAS
CRYOGENIC FLUIDS
DIFFUSION
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
METRONIDAZOLE
MICE
NEOPLASMS
NITRO COMPOUNDS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
X RADIATION