Enhancement of radiation response of a murine mammary carcinoma by two nitrofuran derivatives
Two nitrofuran derivatives, NF-131 [1-(5-nitro-2-furyl)-3-piperidino-1- propanone semicarbazone hydrochloride], and nifuroxime (anti-5-nitro-2- furaldoxime), have been tested for their effect on the TCD50 of a C3H mouse mammary carcinoma and on murine jejunal epithelium. NF-131, at a dose of 2 mg/ mouse, caused a reduction in the TCD50 by a factor of 1.21 to 1.23 when administered iv 3, 10, or 30 min before irradiation. This drug dose had no effect on tumor growth and only a minimal effect on the radioresponse of jejunal epithelium, but caused death in about 3 percent of the mice. Nifuroxime, at a dose of 0.05 mg/g body weight, reduced the TCD50 by a factor of 1.36 when administered ip 10 min before irradiation, but was lethal for 22 percent of the mice. A dose of 0.10 mg/g enhanced the tumor radioresponse by a factor of 1.48 when administered 10 min before irradiation, but by lesser factors at 3 and 30 min. This dose was lethal to 37 percent of the mice. Both doses of nifuroxime inhibited tumor growth temporarily, but neither enhanced the radioresponse of jejunal epithelium. (auth)
- Research Organization:
- Univ. of Texas, Houston
- NSA Number:
- NSA-33-015079
- OSTI ID:
- 4102140
- Journal Information:
- Radiat. Res., v. 64, no. 3, pp. 443-451, Journal Name: Radiat. Res., v. 64, no. 3, pp. 443-451; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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*FURANS-- RADIOSENSITIVITY EFFECTS
*NITRO COMPOUNDS-- RADIOSENSITIVITY EFFECTS
*TUMOR CELLS-- BIOLOGICAL RADIATION EFFECTS
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
CESIUM 137
GAMMA RADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
SMALL INTESTINE
SURVIVAL TIME
TIME DEPENDENCE
WHOLE-BODY IRRADIATION