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EFFECT OF IONIZING RADIATION ON THE REACTIVITY OF THE ANIMAL ORGANISM (in Russian)

Journal Article · · Trudy Vsesoyuz. Konf. Med. Radiol.
OSTI ID:4126125
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Injection of 0.3 ml of an old slightly active filtrate of intestinal rod- shaped bacteria caused a 63.7% increase in leukocytes 24 to 72 hr later in a control group of rabbits. After irradiation (1200 to 1500 r) the same injection caused an average decrease in leukocytes of 35% on the 2nd to 4th day after irradiation. Similarly a subcutaneous injection of 0.1 ml of a culture of staphylococcus aureus resulted in a rapid development of a significant leukocytosis in unirradiated rabbits, but caused only a local festering With no effect on the leukocyte count in irradiated rabbits (l200 r) 24 hr after irradiation. Similarly, radiation caused a change in the animal organism to mobilize leukocytes in response to allergens (Arthus' phenomenon and Schwartzman's phenomenon). On the 6th to 7th day after irradiation the response to the allergen was feeble, but it was normal again 1 1/2 months after irradiation. The action of adrenaline and carbocholine on blood pressure was investigated. On the 10th day after irradiation the blood pressure was 87 mm for the irradiated rabbits and l13 mm for the controls. Injection of adrenaline (0.5 ml per kg of body weight of a 1 i 30,000 solution) caused a rise in blood pressure of 73 mm (94%) in the irradiated rabbits and 62 mm (56%) in the unirradiated rabbits. The injection of carbocholine, especially on the 3rd to 6th day after irradiation, caused a sharp long-lasting drop in blood pressure (by 25 to 30%) in comparison with the control group. 1t was found that cholinesterase activity is more or less at a minimum on the 5th to 6th day after irradiation, but often rises again after this period. (TTT)
Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-15-002513
OSTI ID:
4126125
Journal Information:
Trudy Vsesoyuz. Konf. Med. Radiol., Journal Name: Trudy Vsesoyuz. Konf. Med. Radiol.
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

ANIMALS
BACTERIA
BIOLOGY AND MEDICINE
BLOOD VESSELS
ENZYMES
HORMONES
IMMUNITY
LEUCOCYTES
RABBITS
RADIATION EFFECTS