SEROLOGICAL STUDY OF RADIATION HAZARD. II. THE EFFECT OF X-RAY TO PASSIVE SKIN ALLERGY

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Okayama Igakkai Zasshi (Japan)

OSTI ID:4047969

Murakami, S

White albumin, dissolved in potassium alum solution in a concentration of 1.5 mg/ml was used as antigen, and was injected into the ear vein of a rabbit every other day for 12 times. The whole blood was removed on the 7th day following the last injection, and the separated blood serum was kept in an ice box after the addition of merzonin in the proportion of 1: 10000. The irradiated guinea pigs were injected with the rabbit's serum and were injected again with various concentrations of antigen into the abdominal skin after 24 hr. The skin reaction was examined a day later. After sensitization, 1.5 ml of 0.5% Evans blue solution per kg in weight was injected and immediately 0.1 ml of 1.0, 0.1, 0.01, and 0.001% of antigen was injected subcutaneous in the abdomen, 30 min after which the state of skin reaction was studied. Arthus phenomenon was mostly inhibited on the 7th day after 200 r of x irradiation, and was gradually recovered and showed slightly increased tendency on the 28th day. The area of skin reaction in Arthus phenomenon was minimum on the day following 200 r and showed increased tendency on the 28th day. After 400 r the Arthus phenomenon was mostly inhibited on the 7th day and the area of skin reaction became almost absent. Arthus phenomenon indicated by the Evans blue method showed a maximum area of skin reaction on the 7th day after 200 r, which was diffusely infiltrated with an unsharp margin and then gradually became small and sharply demarcated on the 28th day. The histological changes of the skin in the guinea pig following 200 r were slight with atrophy of the epithelium and no other changes seen. (Absts. Japan. Med., 1: No. 7, 1960.)

• Research Organization: Okayama Univ., Japan
• NSA Number: NSA-15-022120
• OSTI ID: 4047969
• Journal Information: Okayama Igakkai Zasshi (Japan), Journal Name: Okayama Igakkai Zasshi (Japan) Vol. Vol: 71; ISSN OIZAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALBUMINS
ALLERGY
ANTIGENS
BIOLOGY AND MEDICINE
BLOOD SERUM
GUINEA PIGS
IMMUNITY
RABBITS
RADIATION DOSES
RADIATION INJURIES
SKIN
SOLUTIONS
X RADIATION