CHANGES OF NUCLEIC ACIDS METABOLISM DURING INHALATION OF RADON AND SHORT- LIVING PRODUCTS OF ITS DECAY

Journal Article · Mon Aug 01 04:00:00 EDT 1960 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4123289

Rakhmanova, T B

White rats were subjected to the action of radon and short-lived products of its decay. It was established that in single inhalation by rats (for 2 hr) of an air-radon mixure with radon concentration of 0.2 mc/l, the following changes of nucleic acids in the lungs and liver of these animals were observed. In the lungs there was an elevation of the content of both nucleic acids. Restoration of desoxyribose nucleic acid (DNA) as a rnle, did not undergo any change, while the synthesis of ribonucleic acid (RNA) dropped slightly. Analogous changes were also noted in the liver. although with a somewhat larger inhibition of RNA synthesis. These data differ considerably from those cited in the pertinent literature concerning changes of nucleic acids under the effect of medium and large doses of ionizing radiation. Somewhat different data on the spleen, expressed by a sharp inhibition of RNA and DNA synthesis, although with the absence of distinct alterations in the content, were due apparently to a higher radiosensitivity of the spleen in comparison with the lungs and liver. In single two-hour inhalation of an air-radon mixture with 0.8 mc/l radon concentration. the animals develop a characteristic for radiation sickness syndrome with typical changes of nucleic acids. characterized by a sharp decrease of their content and a drop of synthesis. (auth)

• Research Organization: State Inst. of Physiotherapy, USSR
• NSA Number: NSA-15-001282
• OSTI ID: 4123289
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 5, No. 8; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

BIOLOGY AND MEDICINE
LIFETIME
LIVER
LUNGS
METABOLISM
NUCLEIC ACIDS
RADIATION EFFECTS
RADIATION SICKNESS
RADIOSENSITIVITY
RADON
RATS
RIBONUCLEIC ACID
SPLEEN