EFFECTS OF DIFFERENT IONIZING RADIATIONS ON HUMAN CELLS IN TISSUE CULTURE. IV. MODIFICATION OF RADIATION DAMAGE

Journal Article · Sat Feb 01 04:00:00 EST 1964 · Radiation Res.

DOI:https://doi.org/10.2307/3571569· OSTI ID:4120512

Barendsen, G W; Walter, H M.D.

Modification by various treatments of radiation-induced damage in kidney cells of human origin was investigated with 250-kvp x rays and alpha particles from Po/sup 210/. The capacity for clone formation as a function of the radiation dose was found to be influenced sigificantly by the time interval between plating and irradiation, the temperature at which the cells were maintained before and after irradiation, fractionation of the dose, and the presence of oxygen, cysteamine, and glycerol. The modification of the response of the cells was shown to be much more important after irradiation with sparsely ionizing 250-kvp x radiation than with densely ionizing alpha -radiation from Po/ sup 210/. An explanation of the differences between the effects of these radiations has been given on the basis of the differences in spatial distribution of the energy deposition. (auth)

• Research Organization: Radiobiological Inst. of the Organization for Health Research TNO, Rijswijk, Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-011880
• OSTI ID: 4120512
• Journal Information: Radiation Res., Journal Name: Radiation Res. Vol. Vol: 21
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALCOHOLS
ALPHA PARTICLES
BIOLOGY AND MEDICINE
CYTOLOGY
DISTRIBUTION
GLYCERIN
KIDNEYS
MAN
MEA
ORGANIC SULFUR COMPOUNDS
OXYGEN
POLONIUM 210
RADIATION EFFECTS
RADIATION INJURIES
TEMPERATURE
TISSUES
VARIATIONS
X RADIATION