MODIFICATION OF RADIATION DAMAGE BY FRACTIONATION OF THE DOSE, ANOXIA, AND CHEMICAL PROTECTORS IN RELATION TO LET

Journal Article · Tue Mar 31 04:00:00 EST 1964 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1964.tb53565.x· OSTI ID:4022291

Barendsen, G W

Experiments are described on the relation between physical properties of different radiations and the possibilities of modifying the radiation response of cultured human cells by various experimental conditions, using the capacity for clone formation as a criterion. Dose-survival curves are presented for various types of radiation, alpha particles, deuterons, x and gamma rays, and BETA particles and the relation between the relative biological effectiveness and the linear energy transfer is discussed and shown to be dependent on the level of damage considered. Experiments are described concerning the effects of fractionation of the dose. It was found that repair of sublethal damage occurs after irradiation with 250-kv x rays, but is absent after irradiation with alpha particles from /sup 210/Po. The same differences were observed with cells equilibrated with N/sub 2/ during irradiations. Furthermore with single exposures, equilibration of the cells with N/sub 2/ has a pronounced effect on damage produced by 250-kv x rays, whereas only a small protective effect is observed with /sup 210/Po alpha particles. The same differences between effects of 250-kv x-rays and x radiation were found with regard to the protective action of cysteamine. With 250-kv x rays, a dose-reduction factor of 3.7 was obtained at a concentration of 25 mM cysteamine, whereas with alpha particIes from /xup 210/Po a factor of 1.2 was found. The resu1ts are discussed in terms of differences in the spatial distributions of the ionizations produced by the different radiations. (auth)

• Research Organization: TNO, Rijswijk, Netherlands
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019760
• OSTI ID: 4022291
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALPHA PARTICLES
AMINES
ANIMAL CELLS
BETA PARTICLES
BIOLOGY
BIOLOGY AND MEDICINE
CHEMICALS
DEUTERONS
DIAGRAMS
DISTRIBUTION
DOSE FRACTIONATION
ENERGY LEVELS
ETHYL RADICALS
GAMMA RADIATION
IONIZATION
LETHAL DOSE
MEA
NITROGEN
ORGANIC SULFUR COMPOUNDS
POLONIUM 210
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIATIONS
RBE
SURVIVAL TIME
SUSPENSIONS
TESTING
VARIATIONS
X RADIATION