Lymphoid cell kinetics under continuous low dose-rate gamma irradiation: a comparison study. Semiannual status report

Technical Report · Wed Feb 12 04:00:00 EST 1975

OSTI ID:4119424

Foster, B R

The mechanism of cell proliferation is studied in the lymphoid tissue of the mouse spleen under the stress of continuous irradiation at a dose-rate of 10 roentgens per day for 105 days. Autoradiography and specific labeling with tritiated thymidine were utilized. It was found that at least four compensatory mechanisms maintained a near-steady state of cellular growth: (1) an increase in the proportion of PAS-positive cells which stimulate mitotic activity, (2) maturation arrest of proliferating and differentiating cells which tend to replenish the cells damaged or destroyed by irradiation, and (3) an increase in the proportion of cells proliferating, and (4) an increase in the proportion of precursor cells. The results are compared to previous findings observed in the thymus. (STAR)

• Research Organization: Grambling State Univ., La. (USA). Dept. of Physics
• NSA Number: NSA-33-012390
• OSTI ID: 4119424
• Report Number(s): N--75-16213; NASA-CR--142068
• Country of Publication: United States
• Language: English

Related Subjects

*CELL PROLIFERATION-- BIOLOGICAL RADIATION EFFECTS
*SPLEEN CELLS-- CELL PROLIFERATION
560152* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Animals--Vertebrates
COMPARATIVE EVALUATIONS
DOSE RATES
GAMMA RADIATION
IRRADIATION
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates