CHEMICAL PROTECTION OF THE ALIMENTARY TRACT OF WHOLE-BODY X-IRRADIATED MICE. II. CHROMOSOME BREAKS AND MITOTIC ACTIVITY
Journal Article
·
· Exptl. Cell Research
The protective effect of S,2-aminoethylisothiuronium (AET) on mitotic activity and chromosome damage in intestinal crypt cells of x irradiated mice was studied. It was found that the number of chromosome fragments in the crypt cells of both treated and nontreated mice is dose dependent. In lethally x irradiated mice given AET, the number of chromosome fragments was less than that of nontreated mice. At supralethal x ray doses, AET markedly protected mitotic activity. The data indicate that in treated and nontreated mice recovery of mitotic activity was inversely related to the number of chromosome fragments. ( auth)
- Research Organization:
- Oak Ridge National Lab., Tenn.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-007210
- OSTI ID:
- 4119217
- Journal Information:
- Exptl. Cell Research, Journal Name: Exptl. Cell Research Vol. Vol: 21
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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