Neutron field optimization parameters for boron neutron capture therapy
Journal Article
·
· Transactions of the American Nuclear Society
OSTI ID:411520
- Ohio State Univ., Columbus, OH (United States)
Previously, we evaluated moderator assembly designs for an accelerator-based epithermal neutron irradiation facility for boron neutron capture therapy (BNCT) on the basis of parameters that are calculated in air. At present, neutron field design for BNCT is evolving from being based on field parameters in air to being based on parameters that depend on dose distributions in head phantoms, such as the parameters maximum usable depth and therapeutic gain. Gahbauer and his co-workers at Ohio State University have developed a methodology for clinical treatment planning. We have modified this methodology to create a new set of design parameters: the treatment time T and the tumor dose D{sub Tumor}. These parameters are based on dose distributions in head phantoms and include an energy-spectrum-dependent neutron normal-tissue relative biological effectiveness (RBE) and the effects of dose fractionation.
- OSTI ID:
- 411520
- Report Number(s):
- CONF-951006--
- Journal Information:
- Transactions of the American Nuclear Society, Journal Name: Transactions of the American Nuclear Society Vol. 73; ISSN 0003-018X; ISSN TANSAO
- Country of Publication:
- United States
- Language:
- English
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