DISTRIBUTION OF P$sup 32$ IN THE TISSUES OF RAT ORGANS UNDER THE ACTION OF PENETRATING RADIATIONS AND AFTER THE INTRODUCTION OF ACTH

Journal Article · Fri Nov 01 04:00:00 EST 1963 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4112027

Lomonos, P I; Shamakhmudov, A

Distribution of indicating doses of Pa/sup 32/ (20 C/kg) in the tissues of albino rat organs was studied with a view of determining the state of histohematic barries. The objects of investigation were the blood, liver, kidney, spleen, heart, suprarenals, and the brain. Following total exposure to x rays in a dose of 800 r, and after the introduction of ACTH (in proportion of 2 units per 100 g of body weight) no activation whatsoever was rendered on the 1st, 3rd, and 6th day after the exposure. The highest permeability in control animals was revealed in the liver tissue, somewhat lower in the tissue of kidneys, suprarenals, and spleen, and the lowest in the brain. On the 3rd and 4th day of the radiation sickness permeability of the tissues of all the organs under investigation became markedly higher, while on the 1st and 6th day no essential changes were observed. After the introduction of ACTH to unexposed animals a marked increase of permeability was observed in the tissue of suprarenals, and marked changes in blood formules occurred. After the introduction of ACTH on the 3rd day after the exposure the tissue penetrance was lowered, except for suprarenals, where it did not undergo any discernible change, A higher permeability in the tissues of suprarenals was again marked on the 6th day of the radiation sickness course, but at later periods after hormone introduction. (auth)

• Research Organization: Inst. of Experimental Medicine, Academy of Medical Sciences, USSR
• NSA Number: NSA-18-006690
• OSTI ID: 4112027
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 8: No. 11; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

ACTH
ADRENAL GLANDS
BIOLOGY AND MEDICINE
BLOOD
BODY
BRAIN
DIFFUSION
DISTRIBUTION
HEART
HORMONES
KIDNEYS
LIVER
PHOSPHORUS 32
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
RATS
SPLEEN
VARIATIONS
X RADIATION