ERYTHROPOIETIC RECOVERY AND RESIDUAL INJURY IN RATS EXPOSED REPEATEDLY TO X- RAYS
Journal Article
·
· American Journal of Physiology (U.S.)
OSTI ID:4110158
Rats exposed repeatedly to 300-r x rays showed a decrease in Fe/sup 59/ incorporation which attained its lowest point 48 hr pestirradiation. Thereafter iron uptake increased until normal values were measured. This return to normalcy was delayed further with each newly repeated irradiation. On any day during the recovery period, Fe/sup 59/ uptake decreased exponentially with repeated x irradiations. This decrease is a mesure of residual injury to the erythropoietic system. Since, after each repeated irradiation, a reduced amount of Fe/sup 59/ was incorporated at the beginning of the recovery period, while the rate of recovery was similar, it is postulated that the decrease in radio iron uptake is due to an impairment in the functional capacity of the stem cells to proliferate erythrocytes. A working hypethesis for the calculation of erythrocyte stem cell damage is presented. Although the functional capacity of the stem cells to produce erythrorytes was reduced, the daily red cell turnover was normal. Only when this reduction was below a certain limit did a permanent anemia ensue. (auth)
- Research Organization:
- U.S. Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-15-008533
- OSTI ID:
- 4110158
- Journal Information:
- American Journal of Physiology (U.S.), Journal Name: American Journal of Physiology (U.S.) Vol. Vol: 200; ISSN AJPHA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
A MEASURE OF ACUTE RECOVERY AND OF RESIDUAL RADIATION INJURY TO ERYTHROPOIETIC SYSTEM OF RATS GIVEN REPETITIVE X-RAY EXPOSURES
A STUDY WITH Fe$sup 59$ OF THE ERYTHROPOIETIC EFFECT OF THE PLASMA OF RATS IRRADIATED AND MADE ANEMIC WITH PHENYLHYRAZINE
Effect of dried thyroid gland pretreatment upon erythropoietic activity and development of anaemia in sublethally x-irradiated mice
Technical Report
·
Mon Jun 27 00:00:00 EDT 1960
·
OSTI ID:4154298
A STUDY WITH Fe$sup 59$ OF THE ERYTHROPOIETIC EFFECT OF THE PLASMA OF RATS IRRADIATED AND MADE ANEMIC WITH PHENYLHYRAZINE
Journal Article
·
Sat Dec 31 23:00:00 EST 1960
· Acta Physiologica Latinoamericana (Argentina)
·
OSTI ID:4767131
Effect of dried thyroid gland pretreatment upon erythropoietic activity and development of anaemia in sublethally x-irradiated mice
Journal Article
·
Mon Dec 31 23:00:00 EST 1973
· Folia Biol. (Prague), v. 20, no. 1, pp. 59-67
·
OSTI ID:4331429